If you miss one dose of your weekly GLP-1 medicine, it is usually not a big deal. The most important thing is what you do after you miss it. This guide explains exactly what you should do next.
First — Don’t Double Up
Never take two doses to make up for one you missed. Taking a double dose makes it much more likely that you will feel sick, throw up, or have other negative side effects, and it does not give you any extra benefit. Missing one dose will not ruin your progress.
Weekly Injectable GLP-1 Medications
Semaglutide (Ozempic, Wegovy) and Tirzepatide (Zepbound, Mounjaro)
| Situation |
What to Do |
|
Missed dose, and next dose is 4+ days away
|
Inject the missed dose as soon as you remember. Then return to your regular weekly schedule.
|
|
Missed dose, and next dose is less than 4 days away
|
Skip the missed dose. Take your next dose on your regularly scheduled day. Do not take two doses close together.
|
|
Not sure how long it’s been since last dose
|
Skip it and go back to your normal schedule. If you aren’t sure, it is always safer to skip than to take two doses close together.
|
After a missed dose, you may notice:
- Your hunger or food cravings might come back for a little while (this is normal).
- You might feel a little more hungry than usual before your next shot.
- There is no lasting impact on your overall progress from a single missed dose.
Daily Oral GLP-1 Medications
Semaglutide (Wegovy pill) and Orforglipron (Foundayo)
| Situation |
What to Do |
|
Missed dose, remembered the same day
|
Take it as soon as you remember.
|
|
Missed a dose, but almost time for your next dose
|
Skip the missed dose and take the next one on schedule. Never take 2 doses at once.
|
After a missed dose, you may notice:
- Your hunger or food cravings might come back for a little while (this is normal).
- You might feel a little more hungry than usual before your next shot.
- There is no lasting impact on your overall progress from a single missed dose.
Other Oral Medications
Metformin (IR or ER)
| Situation |
What to Do |
|
Missed a dose, remembered the same day
|
Take it as soon as you remember with food.
|
|
Missed a dose, but almost time for your next dose
|
Skip the missed dose and take the next one on schedule. Never take 2 doses at once
|
Contrave (Bupropion / Naltrexone)
| Situation |
What to Do |
|
Missed a dose
|
If you miss a dose, skip it and take your next dose at your normal time. Never take two doses at once.
|
Getting Back on Track
Missing a dose sometimes happens. Here are tips to help you remember:
- Set a weekly phone alarm on your injection day.
- Link your injection to an existing weekly routine like grocery shopping or a regular phone call.
- Keep your medication in a spot you will see it.
- Use your patient portal — your Onsera care team can note your scheduled injection day and help you troubleshoot if you’re frequently missing doses.
When Missed Doses Become a Pattern
If you find yourself missing doses often, talk to your care team. It might happen because:
- You are worried about side effects.
- You are nervous about the shot.
- You have trouble getting the medicine.
- You just forget. Log your weekly injection or daily pill in the Onsera Engage app.
💡 Missing doses often can slow your progress. There is no judgment — just let us know.
Contact Your Care Team If:
- You have missed 2 or more weeks in a row.
- You missed dose(s) because of illness, vomiting, or couldn’t eat.
- You aren’t sure if your specific medication has different rules.
This handout is for educational purposes only and does not replace personalized medical advice from your healthcare provider. Always consult your Onsera care team before making changes to your medications or treatment plan.
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